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Dr. Karen Methling
Institute of Biochemistry
University of Greifswald
Email: methling@uni-greifswald. de
Phone: +49 3834 420-4167
- 11.1970 born in Rostock
- study of chemistry at the University of Rostock
- 1996-2002 PhD work (Synthesis of acyclic analogues of C-nucleosides on basis of push-pull functionalized monosaccaride derivatives) under the supervision of Professor Dr. K. Peseke, Promotion to Dr. rer. nat. (Oganic Chemistry) in 2002
- 2002 – 2012 Postdoctoral work at the University of Greifswald in the groups of Prof. P. J. Bednarski, Prof. W. Siegmund, Prof. M. Nauck and Prof. U. Lindequist
- since 2012 senior researcher in the field of metabolomics in the group of Prof. Michael Lalk
Combination of metabolome analysis with protein engineering
For application of enzymes in the form of whole cells, an understanding of metabolic fluxes in the cells is of interest. We want to extend our metabolomics tools (which are currently applied to systems including only shake flask cultivation) to more complex catalytic setups including homogeneous/photo-catalysis in one-pot. Analysis of the intermediates and products of catalytic reactions and simultaneously monitoring of cell metabolism can help to understand and optimize the reaction conditions.
Collaborations are planned with the groups of Prof. Bornscheuer and Dr. Höhne.